Big Pine Key, United States offers 4 beaches perfect for sunbathing, surfing, swimming, and more. Big Pine Key is known for the National Key Deer Refuge, a sanctuary for the endangered Key deer. The best time to visit Big Pine Key is from November to April, with average air temperatures around 75°F (24°C) and water temperatures near 72°F (22°C). Sandee provides detailed maps, photos, and reviews from fellow beachgoers to help you Choose Your Beach™ and plan your perfect beach vacation!