Santo Domingo, Los Santos, Panama offers 2 beaches perfect for sunbathing, surfing, swimming, and more. Santo Domingo is known for its historic Zona Colonial, a UNESCO World Heritage Site. The best time to travel to Santo Domingo, Los Santos, Panama, is from December to April, with average air temperatures around 80°F (27°C) and water temperatures near 82°F (28°C). Sandee provides detailed maps, photos, and reviews from fellow beachgoers to help you Choose Your Beach™ and plan your perfect beach vacation!