Mytilene, Greece offers 5 beaches perfect for sunbathing, surfing, swimming, and more. Mytilene, South Aegean, Greece, is known for its historic Castle of Mytilene and the renowned Ouzo Plomari. The best time to travel to Mytilene, Greece, is from May to September, when the average air temperature is around 75-85°F (24-29°C) and the water temperature is approximately 72-77°F (22-25°C). Sandee provides detailed maps, photos, and reviews from fellow beachgoers to help you Choose Your Beach™ and plan your perfect beach vacation!